Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy
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چکیده
منابع مشابه
Endemic (Balkan) nephropathy is aristolochic acid nephropathy.
Endemic nephropathy is a syndrome that comprises two entities: chronic interstitial nephropathy and urothelial cell cancers predominantly of the upper urinary tract. The etiological agent for the disease is aristolochic acid, a compound found in the plants of Aristolochia spp. The development of urothelial cancers is characterized by the formation of aristolactam DNA adducts leading to mutation...
متن کاملRestored nitric oxide bioavailability reduces the severity of acute-to-chronic transition in a mouse model of aristolochic acid nephropathy
Aristolochic Acid (AA) nephropathy (AAN) is a progressive tubulointerstitial nephritis characterized by an early phase of acute kidney injury (AKI) leading to chronic kidney disease (CKD). The reduced nitric oxide (NO) bioavailability reported in AAN might contribute to renal function impairment and progression of the disease. We previously demonstrated that L-arginine (L-Arg) supplementation i...
متن کاملAristolochic acid nephropathy: Harbinger of a global iatrogenic disease.
This review constitutes an overview of our investigations of aristolochic acid nephropathy, a chronic kidney disease associated with carcinomas of the upper urinary tract. Our studies began by confirming the hypothesis that chronic dietary poisoning by aristolochic acid was responsible for endemic (Balkan) nephropathy. A unique TP53 mutational signature in urothelial tumors and the presence of ...
متن کاملRisk of urinary tract carcinoma in aristolochic acid nephropathy.
Sir, The article by Yang et al. [1] is of great interest. Indeed, the acknowledgement of the grim reality of aristolochic acid nephropathy (AAN) by Chinese scientists is of paramount importance for public health in Asia. The authors focused on variation in clinical presentation, essentially acute or chronic renal failure as well as tubular disorders. Unfortunately, they do not discuss the cases...
متن کامل«Suspects» in Etiology of Endemic Nephropathy: Aristolochic Acid versus Mycotoxins
Despite many hypotheses that have been challenged, the etiology of endemic nephropathy (EN) is still unknown. At present, the implications of aristolochic acid (AA) and mycotoxins (ochratoxin A-OTA and citrinin-CIT) are under debate. AA-theory is based on renal pathohistological similarities between Chinese herbs nephropathy (CHN) and EN, findings of AA-DNA adducts in EN and in patients with ur...
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ژورنال
عنوان ژورنال: FEBS Open Bio
سال: 2021
ISSN: 2211-5463,2211-5463
DOI: 10.1002/2211-5463.13083